Heewon's Project Reports

• Lead Bioinformatician@Applied Spatial Omics Centre
  Jan 2024 - present

[Biomarker discovery]
1. [SPATIAL-Tx] Spatial Transcriptomics Revealed Alzheimer's Disease Associated Parvalbumin Interneurons Molecular Markers

[Note/scratch]
• Other ASOC project reports



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• Bioinformatician@Arnie Charbonneau Cancer Institute
  Nov 2020 - Dec 2023

[Biomarker discovery]
1. [RNA] Spatial gene expression profiling in GBM
2. [METHYLATION] Establishing epigenetic signatures using PCDHs



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• PostDoc@BHK Lab
  Jan 2018 - Oct 2020

[Biomarker discovery]
1. [WGS] Gemcitabine response prediction and assessment in PDAC PDOs
2. [CELLLINE] Gemcitabine resistance biomarkers of CD73
3. [CELLLINE] Gemcitabine biomarkers in pancreatic cancer
4. [CELLLINE] Associations between NEK10 expression and drug/radio responses
5. [ORGANOIDS] Pharmacological profiles of advanced PDAC PDOs in COMPASS
6. [ORGANOIDS] Pancreatic derived organoid platform for BET inhibitor testing

[Database]

1. [DATABASE] SYNERGxDB
• [PROTOTYPE] cdCocktails
• [PROCESSING] Synergy score calculation

[Notes/scratch]
• Jupyter notebook for biomarker discovery on Azure Databricks



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• Master and PhD student@SNUBI
  Sep 2010 - Aug 2012 and Sep 2012 - Dec 2017

[Biomarker discovery]
1. [MICROARRAY] AgiMicroRNA R Package Analysis
2. [ArrayCGH] Copy number of Squamous cell carcinoma in non-smokers
3. [RNA] Nephrotic syndrome
4. [RNA] Chmp5 Knock-out mice
5. [WXS] Eosinophilia
6. / [WXS] Ritodrine induced side-effects
7. [PANEL] Mercaptopurine neutropenia in ALL
8. [PANEL] Busulfan hepatotoxicity in AML
9. [PANEL] Ritodrine induced side-effects

[Genetic predisposition]
1. [METHOD] Variant, Gene, and Drug scores in Pharmacogenomics
2. [ANALYSIS] Assessment of rare germline mutations for cancer susceptibility with synthetic association study

[Knowledge Base/Tools]
1. [KB] Korean Rare disease Knowledge Base
2. [TOOL] CaReAl: Capturing Read Alignments
3. [TOOL] VVA: Variant Visualization and Annotation

[Note/scratch]
• Available services



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