Bioinformatics Hub

Projects

Examples of how we apply our expertise

Feb 2026

Multi-institute Patient Registry

Dr. Christina Thornton

Innovation

Developing tools and software that push bioinformatics forward

Engagements

Where we gather, teach, and collaborate with the community

Workflow Demos

Executable workflows demonstrating end-to-end, reproducible solutions

Long-Read Metagenomics

Reproducible long-read analysis using Oxford Nanopore reads
(from FASTQ to consensus and reporting)

16S rRNA Amplicon Seq.

End-to-end 16S processing with QC, ASVs, taxonomy, and reporting

Shotgun Metagenomics

QC, host filtering, taxonomic/functional profiling, and reporting
(coming soon)

Collaborators

Partners driving discovery together

Gut Microbiome

Dr. Braedon McDonald

Advancing best practices for microbiome xenografting in murine systems and bioinformatics to profile models against host properties.

Translational Bioinformatics

Ann Zalucky

Developing a quantitative proteomic framework to define early organ dysfunction and lactate dysregulation in sepsis.

Single-cell Transcriptomics

Dr. Markus Geuking

Profiling thymic dendritic cells in germ-free, specific-pathogen-free, and microbiota-xenografted mice using single-cell technology.

Microbiome and Immunity

Dr. Kathy McCoy

Developing and operating IMC bioinformatics workflows to analyze microbe–immune interactions in controlled model systems.

Mucosal Immunology

Dr. Derek McKay

Defining IL4/IL6-driven regulatory macrophage programs and their role in modulating intestinal inflammation.

Medical Informatics

Dr. Christina Thornton

Designing and building a patient registry, accessible online beyond hospital EMRs, to enable multi-institute research in bronchiectasis.

Bioinformatics is Medicine's New Backbone

In modern medicine, bioinformatics is essential for turning biological data into clinical insight. It enables the discovery of disease mechanisms, supports the development of targeted therapies, and helps personalize treatment by aligning interventions with a patient's unique molecular and cellular profile—bringing precision medicine to life.

Projects

Examples of how we apply our expertise

Proteomics in sepsis

Microbiota reproducibility

Gut compartment profiling

Macrophage timecourse

Cytokine-driven macrophages

In Silico Immunopeptidomics

ONT Dorado Run Analyzer

Microbiota and Thymic DCs

Multi-institute Patient Registry

Innovation

Developing tools and software that push bioinformatics forward

Engagements

Where we gather, teach, and collaborate with the community

Workflow Demos

Executable workflows demonstrating end-to-end, reproducible solutions

Long-Read Metagenomics

16S rRNA Amplicon Seq.

Shotgun Metagenomics

Collaborators

Partners driving discovery together

Dr. Braedon McDonald

Ann Zalucky

Dr. Markus Geuking

Dr. Kathy McCoy

Dr. Derek McKay

Dr. Christina Thornton

Bioinformatics is Medicine's New Backbone

Acknowledgement

Dev Environment